EstroG-100® is a patented blend of three botanical extracts designed to support women’s wellbeing during menopause. Non-hormonal, free of estrogenic activity and backed by an international clinical programme.

Composition

• Cynanchum wilfordii (root)
• Phlomis umbrosa (root)
• Angelica gigas (root)
• Blend selected through the screening of more than 70 botanicals
• Rooted in traditional Korean medicine, with over 390 years of documented use

Dosage

• 514 mg/day (dosage used across all clinical trials)
• Alternative registered dosage: 175 mg/day

Clinical evidence

• Global clinical programme comprising 7 clinical trials and over 440 participants, including 5 pivotal trials in more than 300 women across pre-, peri- and postmenopause
• Randomised, double-blind, placebo-controlled studies conducted in the USA, South Korea, India and Iran
• Significant improvements recorded in hot flashes, sleep disturbances, fatigue, nervousness, mood, vertigo, paresthesia, joint discomfort and vaginal dryness (modified Kupperman Menopause Index, MRS-11, MS-TSQ)
• Effects observed as early as 6 weeks and confirmed at 12 weeks
• 52-week study: improvement in femoral bone mineral density and bone metabolism markers
• More than 7 preclinical studies on stress response and inflammatory response

Non-hormonal profile

• No estrogen receptor binding activity (STTA assay on hERα)
• No proliferation of hormone-dependent MCF-7 cells
• No increase in uterine weight in the uterotrophic assay on ovariectomised rats
• Free from isoflavones and phytoestrogens

Safety

• No serious adverse events reported across clinical studies
• No significant changes in body weight, BMI, estradiol (E2), FSH or endometrial thickness
• Blood parameters, kidney function and blood sugar levels within normal ranges
• Recognised as non-toxic by Korea’s Ministry of Food and Drug Safety

Regulatory status

• European Union – authorised Novel Food, Reg. (EU) 2018/469
• United States – FDA New Dietary Ingredient Notification #668
• Canada – Health Canada NPN 80026169 and 80088879
• South Korea – MFDS Health Functional Food Ingredient, approval no. 2010-20
• India – FSSAI 13.6 Health Supplement
• Turkey – registered as a food supplement ingredient

Technical features

• Hot water extraction only, solvent-free process
• No additives or excipients
• Free-flowing fine powder, water-soluble
• Heat-stable
• Shelf life 3 years

Applications

• Capsules, tablets, soft gels
• Gummies and soft chews
• Powders, powder sticks, gel sticks
• Liquids and functional beverages

Manufacturing

• Manufactured by Naturalendo Tech (South Korea), established in 2001
• FSSC 22000, GMP, HACCP and Halal certified
• Over 15 years of international commercialisation

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